I run the tire size you mention with a leveled OME lift, and don't think it looks funny or anything at all. I've gone with this tire size twice in a row as a matter of fact, and don't regret my decision at all. It allows for plenty of tuck, and avoids rubbing issues. It's a very well engineered system, I think the OME lift isn't really a lift for tire size exclusively, as the strut's location in the pathfinder doesn't change much unless you add spacers. Very few tire sizes would fit with the OME that wouldn't fit stock without trimming or the spacers in either case.
I've run several trails, and have done at least 40k miles with both stock suspension with upgraded shocks/struts, and now OME springs with another notch up in rear shocks, and new front struts. The stock suspension does pretty darn well, the places it took me definitely surprised a lot of folks, myself included. My reasoning for going with the OME was not so much clearance, but the way that it handles a load, and especially a rough washboard road (which I run lots of). The amount of control and comfort which it exhibits with the lift is amazing, and I think the perfect blend between load carrying ability and smoothness. It really helps out the back end wander that these Pathfinders tend to have when hitting rough roads. Not only that, but having run some fairly technical trails with the setup, I can say that it performs extremely well if you take your time. The added clearance absolutely makes a difference, but it's the springrate that really makes it shine. That's why I suspect OME doesn't typically go for huge lifts, it's not the raw clearance that you need when you're overlanding, it's a combination of factors that allow it to be capable and comfortable over thousands of miles. Otherwise every Land Cruiser in Australia would be huge. Anyway though, the ride on pavement is excellent, I daily drive mine, and it doesn't ride like an old truck at all. No bounce, nothing. There's also no excess float like the stock tuning tends to have, so I think it strikes about the right balance. I think it actually handles better than stock, definitely cornering a lot flatter. The amount of rear flex available when you add extended shocks is quite surprising too, and I should add that I have had ZERO strut top-out issues with my setup. The gains which a lot of the tires that would fit with an OME versus stock would be fairly minimal for your rear diff anyway, the 245/75s already raise it. For that matter, there's few tires you can run with any 2" lift that wouldn't require some fender trimming, with the result being small gains in clearance at the diff, which I suspect you're unlikely to notice if you're driving roads to trailheads, FS roads, etc.
These are my impressions with the OME lift, but I have my specific reasons for going with it. Hopefully getting some feedback helps you decide, but what I suggest you do, is go with the 245/75r16s, and start hitting the trails you plan on running. See what you like or don't like about the way the Pathy handles it and go from there. If it gets the job done stock, and in a way that you like, there's no reason to change it. Keeping up with the Joneses is a waste of time and money, so just go with what you like, and post some pictures of your travels here.