Many f the issues of sailing liveaboards seem to apply, might check out some sailing forums as the address aspects of just being away from home for extended periods. Some sell the house and buy a boat, some rent it out, some just let family stay. If you rent it, you'll need a manager. You probably won't make much at all off of it unless you own the place free and clear.
You need a tax home, many select areas that don't have personal property taxes and qualifying as a resident usually means at least a driver's license, and you'll need an address. Social Security wants a physical address as a home base but checks are direct deposit. Medicare supplement plans may only have geographic coverage or reduced away from their service area. Need to get a mail service too. Tags and a driver's license can be a problem if they expire and you're 2,000 miles from home.
Money is a factor, saying that you save money away from home or not having rent may not hold water. Fuel, oil, insurance, maintenance, parking fees, tolls, campground fees all adds up, it adds up quickly with some vehicles. Seems like the folks out west, especially in the southwest have desert and open range to venture off road and stay as long as they like. What I'm finding is there are few good spots in the Midwest, fewer east or west coast that you can camp at free. Another article talked about crack downs by municipalities and counties as to overnight parking even on private property like at Wal-Mart or Cosco. Might look up stealth camping. I'm thinking you need to budget for a camp ground every night and if you find a free spot then great. Most campers/vehicles don't have laundry facilities, another expense unless you use a bucket and a clothesline.
Food will cost more on the road than at home, usually. At home, you know where to shop and where to get better deals or better quality foods, not on the road, you're likely going to stop where you can and pay $5 for a bag of ice. Get around tourist areas in the States and the prices go up, or around large metro areas. I've always tried to say that I don't eat more on the road than at home and my food costs should be the same, neither is true. You're more active out in the boonies than in your home, usually, so you need the fuel too.
If you get a large rig, insurance will be another matter traveling full time, I have no idea how expensive that would be but I'm sure it's more than your family auto policy rated in your local area. Several good friends have done the motorhome thing, a couple at the half million dollar mark and smaller Class As, they all seem to need something weekly, you're lucky I guess if you're on the road and you have no issues at all, they aren't a truck or a car. The more goodies there are the more issues you'll have, just more to vibrate, break, come lose and leak.
I don't mean to be raining on a parade, but reality seems far from the dream I'd say. If you're naturally a minimalist you can go on the cheap. Most of the sailing forums say that you'll spend less at home than being out.
I'm thinking of doing some seminars/mentoring in different areas for a couple years, that can take me all over the country. Weekly or bi-monthly stops, an expedition rig of some kind could work, I'm not seeing it being any cheaper than flying to destinations and staying at the Holiday Inn. But, it's not the same thing, I'd rather have fun outdoors, at least in the fall and spring.
I have no plans to go south of the boarder or north except for AK. I already tromped through Europe and North Africa years ago so I'm staying home. All can be much cheaper heading south.
I love my bike too, we would head out and do some camping but plan on a motel from time to time regardless of what your rig is, I see some pretty nice motorhomes at motels. Bad weather forecasts seem to draw them in.