The original Natchez Trace at the ghost town of Old Greenville, MS, the site of the hanging of one of the first known serial killers in America, “Little”
Wiley Harpe. His brother “Big” Micajah Harpe met a similar but less formal end in Kentucky.
Big Harp Little Harp Sign The first known serial killers in American history were the Harp boys. During the years of the Revolutionary War, the two cousins went on an indiscriminate killing rampage, killing anyone who got in their way.